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KMID : 1059520230670020145
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Journal of the Korean Chemical Society
2023 Volume.67 No. 2 p.145 ~ p.149
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Anti-inflammatory, Anti-oxidative and Anti-bacterial Activities of the Constituents Extracted from Leaves of Talipariti hamabo
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Xu Hui Liang
Kim Jung-Eun
Lee Nam-Ho
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Abstract
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Talipariti hamabo is a plant growing around salt marshes in the Lava Coast region of Jeju Island, Korea. In this study, the extract of T. hamabo leaves was investigated for the anti-inflammatory, anti-oxidative and anti-bacterial activities and their active constituents were identified. In the anti-inflammatory tests using lipopolysaccharide-stimulated RAW264.7 cells, the ethyl acetate (EtOAc) fraction inhibited the nitric oxide production without causing cell toxicity. Moreover, the EtOAc fraction reduced pro-inflammatory cytokines (tumor necrosis factor-α, interleukin-6) as well as prostaglandin E2. In the anti-oxidative studies with DPPH and ABTS+ radicals, potent scavenging activities were observed in the EtOAc and n-butanol fractions. Upon the anti-bacterial tests using Staphylococcus epidermidis, EtOAc and n-butanol fractions exhibited good activities.
Through the phytochemical studies on EtOAc fraction, three components were isolated by repeated column chromatography; oleic acid (1), p-hydroxyphenethyl-trans-ferulate (2), nicotiflorine (3). Based on these results, the extract of T. hamabo leaves can be developed as natural resources for cosmetic applications.
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KEYWORD
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Talipariti hamabo, Anti-inflammation, Anti-oxidation, Anti-bacterial, Isolation
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